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Although we found an optimized sequence for the FOXO4 FHD-p53 TAD interaction, it did not show senolytic activity by itself (Figure

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Approach Short trial arm Duration 12 weeks Review Point Week 12 Notes METAOD005 used 12 weeks at oral doses 1-30 mg/day in 300 obese adults

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6 Given the complex management of UC, patients should ideally be managed by a multidisciplinary team comprising gastroenterologists, specialist IBD nurses, dietitians, pharmacists, psychologists, colorectal surgeons and GPs to achieve optimal health outcomes