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Symptoms may include: Rash or hives Itching/swelling of face, tongue, or throat Severe dizziness Difficulty breathing Side Effect 4: Cardiovascular Concerns Some patients may experience cardiovascular-related side effects, including irregular heartbeat and chest pain

On/off cycling here is driven by caution, not by tolerance data: because there is no long-term human safety record, building in scheduled off periods is the conservative research default

Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

RNA 27 , 163173 (2021)

They will also monitor for any unexpected responses during and after the treatment course