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Phase 5: Commercial Launch (Year 8 onward, subject to exclusivity) Final approval cannot become effective before reference product exclusivity expires (12 years from first licensure, plus any pediatric extension)

For those on a plant based diet, fortified foods like plant-based milk, breakfast, cereals, and nutritional yeast can help maintain healthy B12 levels

Another neurological symptom is depression, due to the deficiency leading to higher levels of oxidative stress, DNA damage, and cell death

3 The imbalance in NAD+/NADH ratios can lead to impaired cellular stress responses and metabolic dysfunctions, which are characteristic of metabolic diseases

Having a sufficient amount of B12 in our bodies will improve overall cognitive functioning, as well as ensure that our bodies have enough energy to get through the day