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2), which affect their nuclear translocation and binding to the promoters of specific genes

Kavalactones like kavain and dihydromethysticin may enhance the effects of certain anxiolytic agents and exhibit mild anticonvulsant and antispasmodic effects and these effects are thought to be mediated through non-GABA receptor pathways

For example, they must show good characteristics, biocompatibility, and biodegradability, be water-soluble or form colloids in water, extend cycle half-life, and keep up with FDA requirements

Gout P, Buckley A, Simms C, Bruchovsky N

Such co-localization ensures effective production of LTC 4 at its site of action