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Among potential agents, auranofin (AUR), an FDA-approved drug traditionally used to treat rheumatoid arthritis, has demonstrated potent antitumor activity across multiple cancer types by irreversibly inhibiting TrxR and promoting ROS accumulation [27]

These findings present not only a novel understanding of the pathogenesis of IBD, but may also aid in the development of therapeutic approaches for IBD and other intestinal diseases

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Research indicates that HGF activation provides neuroprotective effects in cerebral ischemia, spinal cord injuries, and traumatic brain damage by promoting neuronal survival, stimulating angiogenesis, and reducing apoptosis