glutathione reductase in caco-2 cells differentiated Apoptosis and glutathione: beyond an antioxidant Multilevel Proteomic Profiling of Colorectal

Recent clinical findings further support the translational relevance of these models, with MNPs now being detected in human atherosclerotic plaques and associated with increased cardiovascular risk

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The absence of oxidative stress presumably prevented cell death under cystine or GSH depletion alone, suggesting that cysteine and GSH cooperate to mitigate oxidative stress

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Among these were DNA damage-inducible transcript 3 (DDIT3), also known as CHOP, and tumor necrosis factor receptor superfamily member 10B (TSFRSF10B), also known as DR5, which have been implicated in apoptotic pathways triggered by the unfolded protein response in the endoplasmic reticulum (ER) (Lam et al., 2020)