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Mitochondrial-Derived Peptide Origins MOTS-c belongs to a small but growing class of peptides discovered to be encoded within mitochondrial DNA rather than nuclear DNA a finding that reshaped scientific understanding of what mitochondria are capable of producing

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By blocking NNMT, it prevents the enzymatic diversion of nicotinamide away from the NAD+ salvage pathway, preserving intracellular NAD+ levels and SAM availability