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The gRNA target (5-CCT TTG ACC GAG CCC ATA TC-3) and single-stranded DNA oligonucleotide (ssODN) donor (5-AGC AGC TCC ACC AAG CAG GAT GGG CAG GAA CAG TTA GTG GTG GGG CAC AAT GTT TCC TTT GCC CGA GCC CAT ATC AGA GAA CAG TAT CTG ATT CAG GTA AGG TTT GTG GGA ATG GAG TGC TGT AAC ATA AGG TGG GCC-3) were synthesized (Integrated DNA Technologies)

Acknowledgements This work was partially funded by the Italian Ministry of Education (MIUR, Grant to GS) and by Sigma Tau Industrie Farmaceutiche Riunite (Grant to GR)

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4) Dosing MAINTENANCE THERAPY FOLLOWING SUCCESSFUL INDUCTION OF REMISSION IN ASUC WHEN TO CONSIDER COLECTOMY DISCUSSION P = 0.007)

Another experiment testified to an ash content of 6.00% for M