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Although they reach virtually every cell in the body in this way, each hormone affects only certain cells, called target cells

Neuroreport 14:14291433

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Additionally, in animal models, riboflavin deficiency was also found to induce down-regulated expression of key osteogenic markers in the femur, including Runx2, Osterix, and BMP-2/Smad1/5/9 cascade [12]