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These data indicate that the Thr1273Glu mutation alters the conformational preferences of the WD40 binding residues in the S tail

Clinical significance [edit] Associations with longevity [edit] FOXO transcription factors have been shown to be the downstream effector molecules of insulin-like growth factor (IGF) signaling pathway

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doi: 10.3892/ijo.2015.2816 192 WolfMTGangulySWangTLAndersonCWSadtlerKNarainRet al

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