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ALDH2 deficiency did not affect liver disease progression but increased HCC risk in cirrhotic HBV patients with AUD ( Additionally, reduced ALDH2 expression in liver cancer tissues correlates with increased tumor growth, migration, and poor prognosis, and this deficiency disrupts cellular redox balance and metastatic potential ( Accumulation of high levels of HBsAg adds another layer of oncogenic stress by inducing ER stress

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