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Rotenone increased microglial activation in both the SNpc and striatum in rats (Sherer et al., 2003a), activated microglia via the NF-B signaling pathway ( Parkinsons disease-associated proteins like -syn, parkin, LRRK2, and DJ-1 have also been reported to activate microglia (Wilhelmus et al., 2012)

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Studies have shown that mitochondrial morphologies are associated with the generation of ROS, and the accumulation of ROS could induce more mitochondrial fragmentation (Willems et al., 2015)

997. Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, et al

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