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To address this, we used a series of orthogonal approaches to test the role of NAD(P) + homeostasis in chemotherapy induced infertility, including treatment with the NAD + precursor NMN, along with transgenic overexpression of the NAD + biosynthetic enzymes nicotinamide mononucleotide adenyltransferase 1 and 3 (NMNAT1 and NMNAT3)

doi: 10.3171/2016.5.jns16243 47 FereshtehnejadS

The dashed black curves show the responses of GSH and fractional hepatocytes to rescue by the standard dose of NAC (36 mM) given over a 1 hour time period starting at two hours after the APAP dose

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Phosphoenolpyruvate carboxykinase is an acid-induced, chromosomally encoded virulence factor in Agrobacterium tumefaciens