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All specimens were fully de-identified

Additionally, curcumin stimulated the activation of MAPK pathway which in turn induced the expression of heterodimers of NF-E2-related factors 2 (Nrf2) that is responsible for ARE activation reporter genes [268]

Moreover, other terpenes were found to effectively inhibit necroptosis/apoptosis/ferroptosis and conferr protection against AP, such as celastrol (Liang et al., 2023), crocetin (Zhu and He, 2022), and glycyrrhizin (Xia et al., 2021) and astaxanthin (Kwak et al., 2021)] exert pancreatic protection by suppressing JAK2/STAT3 hyperactivation, thereby reducing pro-inflammatory cytokine production

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Nat Rev Cardiol 22 , 482496 (2025)