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It is often associated with active lifestyles because it plays a role in energy metabolism

L.Friis RohdeJ.Holm PetersenB.Bruun KorfitsenC.TarpS.et al (2021)

These pathways contribute to cytoskeletal remodeling, extracellular matrix degradation, and the induction of epithelial-mesenchymal transition (EMT), a critical program that endows cancer cells with enhanced motility and invasive capacity [359, 465]