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We propose a predisposition to tissue fragility in patients with clEDS, in particular of the gastrointestinal tract and emphasize the importance of counseling with regard to the risk of gastrointestinal complications

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With the formation of a membrane attack complex, the complementary cascade reaction may be a mechanism of thrombin-induced brain damage, resulting in the lysis of red blood cells (Gong et al., 2005)

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