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In contrast to ghrelin, replacement of I178 4.60 or L181 4.63 by alanine demonstrates a more remarkable decreased GHRP-6s activity than F286 6.58 (Fig

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Principles of bioactive lipid signalling: Lessons from sphingolipids

First, the narrow therapeutic window poses challenges, as NETs exhibit pro-inflammatory effects in the early stage of injury ( 24 hours), making it difficult for systemic administration to achieve precise temporal control