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Brains from male mice but not female mice, treated with intranasal GHK-Cu, only showed a decreased trend for the presence of microglia, suggesting microglia are not a robust target for GHK-Cu at least under the experimental conditions of this study

Additionally, T-IFNAR1 / tumor-bearing mice exhibited a better response to anti-PD- 1 than WT mice (Chen 2022), which also indicates that IFN-I impedes the efficacy of Immune checkpoint inhibition