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51 , 21172123, doi: 10.1373/clinchem.2005.055301 (2005)

Shixian H, Werna T UV, Harm-Jan W, Arnau VV, Ruggero B, Michiel D V et al

Fortes C, Forastiere F, Farchi S, et al

freezing causes ice crystal formation that ruptures peptide bonds irreversibly

Abbreviations A.A: Acetic acid DAI: Disease activity index DSS: Dextran sulphate sodium IBD: Inflammatory bowel disease JAK-STAT: Janus kinase/signal transducers and activators of transcription NF-B: Nuclear factor kappa B Nrf2: Nuclear factor erythroid 2related factor 2 NLRP3: Nucleotide-binding domain, leucine-richcontaining family, pyrin domaincontaining protein-3 NO: Nitric oxide synthase PPAR-: Peroxisome proliferator-activated receptor gamma TLR: Toll like receptor TNBS: 2, 4, 6-Trinitrobenzene sulfonic acid UC: Ulcerative colitis References Buie MJ, Quan J, Windsor JW, Coward S, Hansen TM, King JA, Kotze PG, Gearry RB, Ng SC, Mak JW, Abreu MT