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Comment: Several commenters appreciated our recognition of social risk as a factor in health outcomes and healthcare delivery and agreed that beneficiaries with higher social risk have higher healthcare needs but were concerned about our proposed use of QMB status as a proxy indicator for patients with added social risk

Compounds bearing chloro-substituted phenyl groups at the C4 position showed the most pronounced inhibitory effects: D6, D5, and D3 (Figure 6) best inhibited P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein (BCRP), respectively at low micromolar concentrations of 110 M (for MRP1 and BCRP) and 25 M (for P-gp)

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