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Major drug Interactions: Decongestants Local anesthetics w/ sympathomimetics Antihypertensives CNS depressants Drugs metabolized by P450-2D6 Concomitant use of MAOI's can cause potentially fatal hyperpyretic crisis & seizures History: The therapeutic & commercial success of phenothiazine antipsychotics initiated a large scale search for more effective antipsychotics during the early 1950's

After several washes with Tris buffer, the purified envelopes were re-suspended in the buffer containing 2% Triton X-100 and 0.02% sodium azide

For the Cys-GO electrode, a big spot was observed on the smooth SAM surface, confirming that GO was incorporated in Cys

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