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Activated fibroblasts secrete a significant amount of collagen fibers at the periphery of the granuloma, forming a dense capsule that ultimately creates the three-layer pathological structure of classic gout stones: the inner MSU crystal core, the middle chronic inflammatory granuloma zone, and the outer fibrous capsule

it is used by cells to regulate cell development and metabolism, but can also be used to turn off the expression of foreign genes, such as those of an invading virus