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Symptoms may include: Drooping of the mouth or eyelid Difficulty closing the eye on the affected side Loss of facial expression / asymmetry Possible pain or discomfort around the ear Taste changes or sensitivity to sound (hyperacusis) on the affected side Biomedical (Conventional) Approach 1

In a Treg Cd226 conditional knockout model, female NOD mice also displayed decreased insulitis and diabetes incidence, supporting the notion that CD226 is involved in Treg stability (95)