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2.3 Exogenous influences on oxidative stress and prostate cancer pathogenesis Studies have shown that the majority of PCa patients are diagnosed after the age of 65, with the risk of developing PCa significantly increasing in older individuals [35]

Cytotechnology 71 , 647663 (2019)

Selenium attenuates lipopolysaccharide-induced oxidative stress responses through modulation of p38 MAPK and NF-kappaB signaling pathways

Additionally, in oxidative stress cells, Tripartite Motif Containing 22 (TRIM22) has been found to interact with Keap1 and accelerate the ubiquitination and degradation of NRF2, thereby inhibiting oxidative stress progression and activating ROS/AMPK/mTOR/autophagy signaling pathways