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Current challenges in peptide-based drug discovery

In addition, the feasibility of PRIT as a CD38-based therapy was confirmed in murine models with excellent tumor-to-normal organ ratios of absorbed dose [129]

Improper absorption is linked to other issues with the production of intrinsic factor

These findings support the hypothesis that optimal therapeutic concentration depends not solely on concentration but also on the pathophysiology targeted, injection site, and a standardized protocol

In addition, peptides selectively bind to cell surface receptors and proteins, such as immune checkpoints, receptor kinases, and hormone receptors, subsequently blocking their biological activity or serving as hormone analogs