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However not all the endothelial cells are the same

Other TME-reprogramming engineered microorganisms address metabolite-driven immunosuppression: photosynthetic bacteria (LAB-1) metabolize excess lactate (a TME metabolite that inhibits T cell function) into pyruvate, reducing lactate-mediated immune suppression and restoring CD8 + T cell cytotoxicity (305)

[DOI] [PMC free article] [PubMed] [Google Scholar] Korman T

The present findings were in partial agreement with previous studies

Molecular mechanisms regulating NPPCs in IDD Under conditions of elevated oxidative stress, excessive reactive oxygen species (ROS) accumulation and mitochondrial damage activate senescence pathways like P53/P21, contributing to accelerated ECM catabolism and NPPC senescence [76]