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These changes increase membrane permeability, affect membrane protein function, and lead to ion imbalance, particularly the influx of calcium ions, which in turn causes muscle fiber damage (36)

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Larger doses of vitamin B12 can cause other more serious side effects including: Headache Nausea and vomiting Diarrhea Fatigue or weakness Tingling sensation in hands and feet Our doses are preservative free and extremely small, and therefore rarely cause a negative reaction

doi: 10.1111/micc.12117, 18

Dominant and diet-responsive groups of bacteria within the human colonic microbiota