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Megalencephalic leukoencephalopathy with subcortical cysts (MLC), is another primary leukodystrophy caused by recessive pathogenesis variants in the genes MLC1 (Modulator of VRAC Current 1) or HEPACAM (Hepatic and Glial Cell Adhesion Molecule, previously known as GlialCAM ) 338

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They starred in their own reality television series, Khlo & Lamar (20112012)