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By selectively inhibiting NNMT an enzyme central to energy regulation and fat metabolism this compound has demonstrated, in preclinical studies, the capacity to elevate intracellular NAD and SAM levels, suppress lipid accumulation in adipocytes, and reduce white adipose tissue mass in diet-induced obese mouse models

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doi: 10.1161/CIRCRESAHA.115.304185

Following a 1 h incubation at 28 C, the migration of neutrophils in transgenic zebrafish was assessed using a live imaging approach with an inverted fluorescence microscope (Nikon, Inc.)