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ALC is widely distributed in mammalian tissues, including the brain, bloodbrain barrier, brain neurons, and astrocytes

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This is supported by large-scale cohort studies that identified increased plasma lactate in BD patients (e.g., FACE-BD and I-GIVE cohorts, 837 and 237 BD patients, respectively) [2]

This was associated with reduced mitochondrial respiratory chain complex IV activity and loss of mitochondrial membrane potential, respectively, and increased apoptosis (188, 189)