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Bruck R, Benedetti A, Strazzabosco M, Boyer J

Ranasinghe SL, Fischer K, Zhang W, Gobert GN, McManus DP

Quite recently, experiments conducted using mice kidney and tubular cells showed that cisplatin-induced kidney inflammation might be governed by the activation of poly(ADP-ribose) polymerase-1 (PARP-1), an enzyme which in the hyperactivated state decreases the rate of glycolysis and impairs electron transport and ATP formation, which eventually leads to dysfunction and/or death of various normal cell types