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131 Moreover, luteolin treatment reduces lymphocyte infiltration in the thyroid gland as well as downregulates IFN-, TNF-, and COX-2 expression and the STAT1 and STAT3 signaling pathways during T cell activation in a mouse model of experimental autoimmune thyroiditis

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Electrophilic reagents such as diethyl maleate (DEM) and isothiocyanates (ITCs) can diminish GSH in the presence of GST, but the high reaction activity of these reagents makes them low targeting and easy to damage normal tissues [10]

Statistical significance was assessed by by ordinary two-way ANOVA in a , and by unpaired two-tailed t-test in b , c

Acknowledgements This open-access review paper was supported by The project New Technologies for Translational Research in Pharmaceutical Sciences /NETPHARM, project ID CZ.02.01.01/00/22_008/0004607, is co-funded by the European Union, and the Erasmus+ Programme of the European Union, Key Action 2: Strategic Partnerships, Project no