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Both in vitro and in silico experiments also showed lauric acids cytotoxicity towards murine macrophages, HepG2 (human hepatocellular carcinoma), and HCT-15 (human colon cancer) cells

10.1155/2021/8774010 Mahmoud Nassar, Nso Nso, Luis Medina, Victoria Ghernautan, Anastasia Novikov, Alli El-Ijla, Karim M Soliman, Yungmin Kim, Mostafa Alfishawy, Vincent Rizzo, Ahmed Daoud

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The results showed that ERK, JNK and P38 were all activated after MIRI (Figures 7A, B), among them, Sat1 inhibition only significantly suppressed the activation of MAPK/ERK, but Sat1 over-expression did not significantly promote the activation of MAPK/ERK (Figure 7B)