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[Epub ahead of print] doi: 10.1002/hep.30109

Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity

Medication use is another important risk factor, with patients on long-term opioids, anticholinergic agents, calcium channel blockers, and antidepressants demonstrating a significantly increased constipation incidence (Coyne et al., 2014)