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Therefore, our findings showing that ubiquitylated IL-1, akin to the IL-1 K133A or D129A mutants, is inefficiently cleaved by Caspase-1 raises the interesting possibility that IL-1 K133 ubiquitylation impacts the integrity of the K133:D129 electrostatic interaction to limit caspase-1 processing

Mucositis, Periodontitis & Gut-Oral Axis KPV is particularly relevant for patients with refractory periodontitis, pericoronitis, chemotherapy-induced oral mucositis, or chronic low-grade gingival inflammation unresponsive to conventional scaling

Human data are limited, so its real-world benefits and safety in people are not well established

In this sense, the aim is to find out whether it is possible to control the cell death process via ferroptosis by means of food or nutritional supplementation