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Prodrugs of GST Both conventional chemotherapeutic and targeted agents have well-established toxicity profiles, with a wide range of adverse effects, eg, bone-marrow suppression, gastrointestinal toxicity, immunosuppression, gastrointestinal toxicity, hepatotoxicity, and cardiotoxicity

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The full information of candidate metabolites (metabolite name, HMDB ID, KEGG ID, PubChem ID, comparison group, tissue, organism, category of depression model, platform, and regulation direction) is presented in Supplementary Data 4

Nrf2 upregulates ATP binding cassette transporter expression and activity at the blood-brain and blood-spinal cord barriers

Figure 3 3.1 Pharmacological modulation of bile acid signaling Pharmacological targeting of bile acid (BA) signaling, a critical regulator of the TIME ( 3.1.1 Farnesoid X receptor modulators: a context-dependent balancing act FXR, pivotal in BA homeostasis and inflammation, presents a dual-faceted therapeutic target (127)