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Wegovy Tablet (NEW): Once-daily oral semaglutide 25 mg Average weight loss: 16.6% ~1/3 of patients achieved 20%+ weight loss Approved specifically for weight management Reduces cardiovascular event risk Rybelus (Available in Canada): Once-daily oral semaglutide 14 mg max Average weight loss: ~4% Originally approved for Type 2 Diabetes Prescribed off-label for weight loss The Verdict: Wegovy tablet is significantly more effective for weight loss - achieving results comparable to weekly Wegovy injections while Rybelus falls short at lower doses

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The primary endpoint was change in HbA 1c (%-points) from baseline to week 40