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In addition, ascorbate has the capacity to reduce free redox-active transition metal ions, such as copper and iron

das Neves, J., Amiji, M

Ogrodnik M, Carlos Acosta J, Adams PD, dAdda di Fagagna F, Baker DJ, Bishop CL, Chandra T, Collado M, Gil J, Gorgoulis V, Gruber F, Hara E, Jansen-Drr P, Jurk D, Khosla S, Kirkland JL, Krizhanovsky V, Minamino T, Niedernhofer LJ, Passos JF, Ring NAR, Redl H, Robbins PD, Rodier F, Scharffetter-Kochanek K, Sedivy JM, Sikora E, Witwer K, Zglinicki Tv, Yun MH, Grillari J, Demaria M

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In diabetes, persistent hyperglycemia and mitochondrial dysfunction lead to elevated ROS production, intensifying OS [149]