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Another study identified several recurrent somatic mutations in NF1-linked and sporadic cNFs, including MAML3, TAS2R30, DNAH3, KIAA0040, NDUFS7, SSPO and UBXN11

Higher daily doses and rapid tapering schedules exacerbate withdrawal symptoms and delay recovery

Thirdly, GPX4 levels decreased in cartilage from the OA animal models, and knockout of GPX4 exacerbated mice experimental OA process [111]

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The pathophysiology of oxidative stress and inflammation is essential in understanding the role of antioxidants and anti-inflammatories as immunomodulators