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Response to Retention Hypothesis for the Initiation of Atherosclerosis The response to retention hypothesis holds that retention of atherogenic lipoproteins in the artery wall is a critical initiating event that sparks an inflammatory response and promotes the development of atherosclerosis (Figure 1)

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And, as contemporary science continues to validate its key mechanisms, it will continue to help well-trained individuals achieve real physique and performance improvements for years to come