There is increasing evidence that aberrant accumulation of mut-p53 leads to gain-of-function activities in cancer cells 30
In conclusion, although antioxidant strategies represent a very promising approach to slow the progression of the disease, it is of utmost need to invest on the characterization of OS profiles representative of each subtype of patient, in order to develop personalized therapies, allowing to understand the characteristics of antioxidants that have beneficial effects on different subtypes of patients
The conditions that have been associated with glutathione deficiency include the following: Neurodegenerative diseases such as Alzheimers, Parkinsons and Huntingtons disease and ALS Pulmonary diseases such as COPD, asthma, and acute respiratory distress syndrome Immune system disorders Cardiovascular diseases such as high blood pressure, elevated cholesterol, and heart attacks Chronic age-related disorders such as cataracts, macular degeneration, hearing impairment, and glaucoma Liver disease Cystic fibrosis Aging processes (Pizzorno, 2014)
Glutathione can shift melanin synthesis toward lighter pigment in laboratory settings and a handful of small studies, which is the mechanistic seed behind the marketing
[7] last access: 11.01.2023 [8] last access: 11.01.2023 [9] last access: 11.01.2023 [10] Buck, MJ, Lieb, JD
