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The RNA-dependent RNA polymerase (NSP12) and helicase (NSP13) of the replication-transcription complex (RTC) are the most conserved proteins when considering the rate of change at each amino acid site (homologies or nucleic acid diversity) over the course of the SARS-CoV-2 pandemic or conservation in sequence across HCoVs and the coronavirus family [62]

06 Confusion between routes Subcutaneous, oral, transdermal, and intranasal AOD-9604 use very different doses

10.1038/s41390-018-0191-9 Pediatr

Nevertheless, in some clinical studies, contradictory findings have been reported