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Factors that influence speed of results include: starting weight dosage adjustments consistency with treatment nutrition habits activity levels sleep quality metabolic health Gradual, steady weight loss is generally more sustainable than rapid short-term results

They include megaloblastic anemia, lethargy, failure to thrive, microcephaly, brain abnormalities, developmental delay, intellectual deficit, seizures, and retinopathy

Researchers planning protocols are referred to the original primary literature cited in the References section for full methodological detail