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IGF-1 was also found to increase intramuscular nerve sprouting ten fold when it was given to normal adult rats

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doi:10.1083/jcb.200201070 Jenstad M, Quazi AZ, Zilberter M, Haglerod C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM , Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA (2009) System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate

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So far, estimations of this all-important parameter have relied on the use of destructive methods which cannot discriminate between cellular compartments and display significant reproducibility shortcomings