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Primary astrocytic leukodystrophies Alexander disease (AxD), the first known monogenic disease originating in astrocytes, is caused by toxic gain-of-function mutations in GFAP manifested by severe white matter damage 330,331

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We believe that the best way to approach this topic is to focus and highlight the outcomes and importance of the pentose phosphate pathways as opposed to the specific enzymes, as this is most likely how the MCAT will test you on this topic