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Our recently conducted preclinical studies in the penetrating TBI animal model, demonstrated zero toxic effects for IP-administered NACA at the highest concentration (600 mg/kg), supporting a safer profile for its use as a mitochondrial-targeted neuroprotection compound for TBI (unpublished data)

However, CJC-1295 has a longer half-life compared to MK-677

Pirfenidone attenuates bleomycin-induced pulmonary fibrosis in mice by regulating Nrf2/Bach1 equilibrium

1) include 12 genetically distinct metabolic disorders, inherited as an autosomal recessive trait, with an estimated cumulative incidence from 1:6,500 to 1:110,000 [1]

To view a copy of this licence, visit About this article Cite this article Errichetti, E., Zabotti, A