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We summarize the main environmental and ecological factors that can influence the host-parasite interaction in polluted environments (Figure 2), including (i) the type of pollutants mixture, their probabilities of occurrence, and their chemical properties (accumulation, metabolization, differential toxicity among species, etc.), (ii) the nature and intensity of parasites, tolerance to pollutants, the ability to sequester pollutants, life cycle (number of obligatory hosts), diversity of parasites species, and dynamics of co-infection, and (iii) host tolerance and resistance to parasites, tolerance to pollutants, individual traits (sex, age, body length, trophic ecology, etc.), and inter- and intra-specific relationships

Overall, the biochemical mechanisms of COVID-19-induced tissue damage are complex and involve a range of metabolism-disturbing processes, including inflammation, hypoxia, energy deficiency, and accumulation of metabolic intermediates [45]

Transplantation of human glial progenitors to immunodeficient neonatal mice with amyotrophic lateral sclerosis (SOD1/rag2)

Acting as a glutamate-cystine antiporter, inhibition of the Xc system may lead to depletion of the intracellular cysteine pool, one of the molecular events that induces ferroptosis (2,7,21,28)

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