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Nonetheless, within tumor-bearing hosts, DCs often exhibit an immature and malfunctioning phenotype due to the limited tumor immunogenicity and the presence of immunosuppressive agents secreted by either tumor cells or tumor-associated immunosuppressive cells, thereby allowing tumors to evade immune surveillance [39, 40]

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10.1039/C6RA13075E 38 DayZ

492 Mutant IDH abnormally accumulates D-2-hydroxyglutarate (D-2-HG), triggering epigenetic reprogramming and blockade of cell differentiation, which are particularly prominent in gliomas and hematological malignancies

doi: 10.1016/j.phymed.2021.153894 45 ZongYLiHLiaoPChenLPanYZhengYet al