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Referral to secondary care is indicated for severe or rapidly progressive neurological symptoms, diagnostic uncertainty, suspected bone marrow failure, or in pregnancy or paediatric cases

Chitin-based hydrogel loaded with bFGF and SDF-1 for inducing endogenous mesenchymal stem cells homing to improve stress urinary incontinence

doi: 10.1038/s41588-018-0099-7 39

In normal tissue, the process of neovascularization is tightly controlled

Each element of the blood transport mechanism to the heart, when failing, sequentially causes blood stasis in the veins, the development of inflammation, damage to the endothelial layer lining the vessel, subsequently forming a thrombus that prevents blood transport to the heart