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AIS: acute ischemic stroke Akt: protein kinase B BBB: blood-brain barrier Ea: electroacupuncture ECM: extracellular matrix GLP-1: glucagon-like peptide-1 GLP-1R: glucagon-like peptide-1 receptor HT: hemorrhagic transformation I/R: ischemia/reperfusion IGF-1: insulin-like growth factor-1 MCAO: middle cerebral artery occlusion miRNA: microRNA MMPs: matrix metalloproteinases MQC: mitochondrial quality control MSCs: mesenchymal stem cells NA-1: nerinetide NBP: 3- N -Butylphthalide NF-B: nuclear factor-kappa B NSCs: neural stem cells NVU: neurovascular unit PI3K: phosphoinositide 3-kinases STAIR: Stroke Treatment Academic Industry Roundtable TCM: traditional Chinese medicine TH: therapeutic hypothermia TIA: transient ischemic attack TLR4: Toll-like receptor 4 The authors would like to express their gratitude to the respective authors and scidraw.io for generously providing the original figure material in this article

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